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However, both systematic and intra-NAc shell Ex-4 successfully decreased oxycodone self-administration and cue priming-induced reinstatement of oxycodone seeking-behavior in mice without causing adverse feeding behaviors or changing analgesic effects of oxycodone (Zhang et al., 2020)

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Research shows that for every kilogram of weight lost during a caloric deficit, approximately one-third can come from muscle mass unless specific steps are taken to prevent it